Vision rehabilitation uses devices and strategies to assist individuals with vision loss to address their individual goals and maintain independence and quality of life. Reading is the most common goal that individuals with vision loss bring to vision rehabilitation, yet the most efficient and effective methods to assist such patients have not been identified. There are contrasting clinical methods for reading rehabilitation used in Europe and the United States. In addition, new information about the neuroplastic changes that accompany the loss of central vision are evolving, yet those who are doing such research in functional neuroimaging have limited contact with vision rehabilitation clinicians. This seminar will focus on reading rehabilitation, encourage open debate between basic researchers and clinicians, and lead to the formation of plans for optimal, collaborative research designs testing new hypotheses.