Critically ill patients with acute brain injuries require close monitoring of systemic and central nervous system physiology, as real-time changes in homeostasis impact emergency treatments such as titration of blood pressure, normalization of temperature, and correction of the intracranial milieu. To provide such life support and intensive care, modern neurological and neurosurgical critical care units (i.e., neurocritical care) employ an impressive array of technologically sophisticated instrumentation to track the physiological state of each patient. The clinical staff assimilates and interprets the resultant high-resolution and multiparameter physiologic data streams to develop pathophysiological hypotheses that guide therapeutic decisions. While these data streams often require invasive measurements and are an integral part of the clinical decision-making process, they are currently not considered part of the medical record and are therefore not archived permanently. This leads to significant loss of valuable information that could be analyzed to improve patient care and to understand the physiology of the injured brain. This workshop engages experts in neurocritical care, neurosurgery, computational physiology, and statistics to explore prospective archiving and systematic analysis of large volumes of physiological and clinical information collected in the neurocritical care environment.