Our exploratory seminar will address one of the major challenges health systems will be confronting over the coming decades—incorporation of precision medicine in health systems. The Radcliffe Institute offers a unique environment to bring together leading healthcare practitioners with a cross-disciplinary group of scholars from the schools of public health, law, government, and business to work on proposals for policy interventions and regulatory changes that will better prepare health systems for precision medicine. The structure of the seminar will consist of two parts. First, we focus on two cases that are at the forefront of translating the science of precision medicine into clinical practice to examine opportunities and constraints that exist within current health system structures. The two cases focus on the following novel platforms for the collection, exchange, and analysis of advanced molecular diagnostics information: 1) the Geneinsight platform, which was developed by Partners Healthcare Precision Medicine, and 2) c360, a platform that is being developed by Cepheid for use in conjunction of GeneXpert diagnostics devices, which play an important role in WHO efforts to combat TB. These cases are at opposite ends of the healthcare spectrum – i.e., resource-poor vs. resource-rich healthcare settings; a focus on infectious diseases vs. non-communicable diseases. Yet, the cases bring to the forefront similar constraints in advancing precision medicine. The cases will provide segue to the second part of the seminar about policy recommendations and regulatory proposals. The invited speakers have been selected with an eye on addressing two aspects of health systems design that we believe to be of particular importance to the advancement of precision medicine, the development of 1) new frameworks for the collection, use, and ownership of patient data, and 2) new provider payment and reimbursement models.