River Monster: The Epidemiology, Ecology, and Pathobiology of Cholera

Monday, October 22, 2012


John Mekalanos discusses the biology of cholera, driven by his investigations on the molecular genetics of the causative bacterial organism. With his many colleagues in Bangladesh, Haiti, and elsewhere, he has provided strong evidence for how this organism emerged as a human pathogen and has recently become more pathogenic, as well as for why epidemics begin and end so abruptly. He applied this knowledge to the construction of genetically stable cholera vaccines that have been successfully tested in the United States and Bangladesh.