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Esti Yeger-Lotem is an assistant professor in the Faculty of Health Sciences and a member of the National Institute for Biotechnology in the Negev at the Ben-Gurion University of the Negev. Inspired by the observation that biological molecules do not work in isolation but through interactions with other molecules, Yeger-Lotem’s research uses molecular interaction networks to model and analyze cellular processes.
During her stay at Radcliffe, Yeger-Lotem is expanding her research of the molecular basis of tissue-specific hereditary diseases. Caused by mutations present in the entire body, these diseases manifest clinically in a small subset of tissues and cell types, while all other tissues and cell types remain intact. By taking advantage of the vast amounts of recently acquired molecular profiles and by harnessing methodologies from the field of networks, Yeger Lotem’s research will open new avenues in understanding this enigma.
Yeger-Lotem holds degrees in biology (BSc) and computer science (MSc and PhD), and she has worked at IBM Research. She conducted postdoctoral research at the Whitehead Institute for Biomedical Research and the Massachusetts Institute of Technology, where she developed innovative approaches to model and decipher disease pathways based on heterogeneous data. She has received various honors, including an EMBO Fellowship, the IBM Outstanding Technical Achievement Award, the Marie Curie Career Integration Grant, and a research grant from the National Parkinson Foundation. The powerful web tools that her lab develops to integrate heterogeneous data and to decipher cellular pathways are used worldwide.