Exploring the Landscape of Functional Proteins by Computational Design
A presentation from 2022–2023 Grass Fellow Bruno Correia
Bruno Correia joined the École Polytechnique Fédérale de Lausanne (EPFL) as an assistant professor in 2015. His research group focuses on developing computational tools for protein design with particular emphasis on applying these strategies to immunoengineering, e.g., vaccine and cancer immunotherapy. Recently, his lab introduced novel ways of describing protein molecules based on surfaces’ chemical and geometrical features.
During his sabbatical, Correia will investigate how to use a geometric perspective on molecular structures to understand key phenomena in the immune system, such as immunogenicity and self- vs non-self-discrimination. The driving principles of such phenomena may have an impact on practical applications, such as the design of improved vaccines and biologics.